大阪大学 先導的学際研究機構

RNAフロンティアサイエンス部門

English

PUBLICATION

Member’s publication

 

2026

  1. Anindita J, Tanaka H, Oyama R, Matsumaru A, Nakai Y, Tange K, Nagaoka K, Nakanishi H, Kawamura T, Tanaka T, Yamashita T, Kuroda A, Nomura S, Hatakeyama H, Itaka K, Kodama T, Kakimi K, Akita H. Combination of ionizable lipids with oleic acid and vitamin E scaffolds for RNA cancer vaccine delivery. J Control Release. 2026 Jan 10:389:114414. doi: 10.1016/j.jconrel.2025.114414. 　
  2. Hsieh L, Wiguna FJ, Adhitama N, Kato Y, Watanabe H. Juvenile hormone analog, fenoxycarb induced apoptotic effects in the developing ovary of Daphnia magna. Aquat Toxicol. 2026 Feb;291:107699. doi: 10.1016/j.aquatox.2025.107699. Epub 2025 Dec 29. PMID: 41485427. 　
  3. Tsuji Y, Wiguna FJ, Adhitama N, Religia P, Kato Y, Watanabe H. Production and accumulation of recombinant protein via vitellogenin transport pathway in Daphnia magna. J Biotechnol. 2026 May 4:S0168-1656(26)00137-9. doi: 10.1016/j.jbiotec.2026.04.015. Epub ahead of print. PMID: 42092404. 　
  4. Yoo H, Nakahama T, Sugihara R, Gao Y, Ishizawa Y, Yang J, Ni Z, Iwasaki M, Kato Y, Kawahara Y, Aberrant Multicellular Interferon Signaling Underlies Adar1 Mutation-Driven Aicardi-Goutières Syndrome-like Encephalopathy. Cell Reports. 45(4): 117113, 2026. 　
  5. Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya, Ryutaro Kotaki, Kazuaki Kameda, Ryo Koyama-Nasu, Kazuki Okuyama, Ken-ichi Hirano, Hiroyuki Hosokawa, Katsuto Hozumi, Masato Ohtsuka, Takahiro Kishikawa, Chikako Shibata, Motoyuki Otsuka, Reo Maruyama, Kiyoshi Ando, Tomohiro Kurosaki, Hiroshi Kawamoto, Ai Kotani. A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency. Elife . 2026 Feb 6:13:RP101510. doi: 10.7554/eLife.101510.　
  6. Akane Kanamori, Akira Hasuike, Kai Kudo, Joaquim Carreras, Takanobu Shimizu, Shunya Nakayama, Ryo Yanagiya, Ryo Koike, Yorimasa Ogata, Osamu Takeichi, Shuichi Sato, Kiyoshi Ando, Naoya Nakamura, Makoto Murakami, Kenichi Imai, Ai Kotani. EBV Promotes Alveolar Trabecula Resorption via Extracellular Vesicle Remodeling by Group IIA Secreted Phospholipase A2 J Lipid Res . 2026 Mar 3:101014. doi: 10.1016/j.jlr.2026.101014. Online ahead of print. 　
  7. Osawa T, Yamashita R, Koyama H, Fujisue D, Obika S. Amidation of Phosphonoacetate-Modified Oligonucleotides and Evaluation of the Properties of the Synthesized Oligonucleotides. Org Lett. 2026 May 1;28(17):5418-5423. doi: 10.1021/acs.orglett.6c01036. 　
  8. Ban I, Orita A, Yoshikawa H, Ito K, Obika S, Imanishi T. BNANC clamp PCR for simple and sensitive detection of KRAS and EGFR mutations. Bioorg Med Chem. 2026 Jul;138:118656. doi: 10.1016/j.bmc.2026.118656. 　
  9. Kawai K, Matsumoto S, Harada A, Sada R, Harada T, Kasahara Y, Obika S, Okamura Y, Kikuchi A. Development of ARL4C antisense oligonucleotide with reduced off-target effects and enhanced efficacy as an anti-cancer drug. In Vitro Cell Dev Biol Anim. 2026 Apr;62(4):413-427. doi: 10.1007/s11626-026-01154-2. 　
  10. Simanihuruk V, Kida Y, Takada K, Yamaguma H, Kameoka N, Anzai I, Shichinohe S, Obika S, Kasahara Y, Watanabe T. Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses. iScience. 2026 Jan 29;29(3):114851. doi: 10.1016/j.isci.2026.114851. 　
  11. Akita T, Tomita-Sudo E, Sano R, Sakimoto N, Iwai S, Nankai H, Obika S, Inoue T, Kawakami J. Effects of N-1-Mer Impurities in Antisense Oligonucleotides on the Target RNA Suppression. Nucleic Acid Ther. 2026 Apr;36(2):109-116. doi: 10.1177/21593337261419436. 　
  12. Takayama M, Tsubota T, Yamaguchi T, Chiba K, Yoshida T, Hari Y, Tian YS, Takaya D, Mori A, Tsukamoto T, Ishimoto K, Ago Y, Okada Y, Sakamoto K, Doi T, Fukuzawa K, Obika S, Nakagawa S, Hino N. Genetic Encoding of a Trifunctional Photo-Cross-Linker with a Cleavable Alkyl Ester Moiety. Chembiochem. 2026 Feb;27(3):e202500827. 　
  13. Nakajima S, Miyakawa S, Ohno S, Ikemoto H, Maruyama R, Chiba K, Suginaka R, Oda C, Kasahara Y, Fukuzawa K, Obika S, Yamaguchi T. Sequence-dependent RNA cleavage by the 8-17 DNAzyme: Identification of preferred tetranucleotide motifs. Bioorg Med Chem. 2026 Mar:134:118520. doi: 10.1016/j.bmc.2025.118520. Epub 2025 Dec 14. 　
  14. Togawa H, Yamaguchi T, Kawakami J, Obika S. Current trends in liquid chromatography-mass spectrometry analysis of small interfering RNAs: A short review. J Chromatogr A. 2026 Jan 11;1766:466550. doi: 10.1016/j.chroma.2025.466550. 　
  15. Uchida Y, Yoshida T, Saito E, Nankai H, Karasawa K, Inagaki C, Iwasaki N, Higo D, Takahara K, Osawa T, Yamaguchi T, Ito K, Kawakami J, Obika S, Inoue T. Theoretical calculation of the amounts of nucleotide deletion impurities in oligonucleotides. Int J Pharm. 2026 Jan 5;687:126364. doi: 10.1016/j.ijpharm.2025.126364. 　
  16. Miyazaki T, Asano N, Yamaki S, Yamaguchi T, Obika S. Hydrophilic additives enhancing electrospray ionization of oligonucleotides in hexafluoro-2-propanol-free reversed-phase ion-pair liquid chromatography/mass spectrometry. J Chromatogr A. 2026 Jan 4;1765:466485. doi: 10.1016/j.chroma.2025.466485. 　
  17. Ito T, Yoshino M, Isobe SY, Obuse C.RLF/ZFP292 stabilize CoREST-linked LSD1 engagement at bivalent promoters to safeguard pluripotency. Cell Rep. 2026 Apr 16;45(4):117293. doi: 10.1016/j.celrep.2026.117293. Online ahead of print. PMID: 41996247 　
  18. Feng Z, Takashima T, Nagata H, Shintani Y, Morii E. Rho-associated coiled-coil-containing protein kinase signaling preserves alveolar type II cell identity by antagonizing transforming growth factor-β1-driven epithelial remodeling in idiopathic pulmonary fibrosis. Exp Mol Pathol. 2026 May 6;146:105048. doi: 10.1016/j.yexmp.2026.105048. Online ahead of print. PMID: 42096940 　
  19. Mishra SK, Hicks SM, Frias JA, Zhang J, Handley MT, Vangaveti S, Reid TS, Pandey A, McMichael O, Crumbaugh C, Provenzano M, Hale MA, Johnson NE, Nakamori M, Cleary JD, Reddy K, Berglund JA. Identification of enzymatically modified isoquercitrin as a therapeutic lead for myotonic dystrophy type 1.NAR Mol Med. 2026 Jan 29;3(1):ugag007. doi: 10.1093/narmme/ugag007. 　
  20. Takakuwa H, Yoda T, Yamazaki T, Hirose T. Blocky proline/glutamine patterns in the SFPQ intrinsically disordered region dictate paraspeckle formation as a distinct membraneless organelle. RNA. 2026 Apr 16;32(5):688-703. doi: 10.1261/rna.080769.125. 　

2025

  1. Iwasaki M. Multifunctional noncoding regions in the mammarenavirus genome. Virology. 2025. In Press. doi: 10.1016/j.virol.2025.110464. Review.
  2. Minami S, Nouda R, Hirai K, Z. Chen, Kotaki T, Kanai Y, Kobayashi T. Establishment of reverse genetics systems for Colorado tick fever virus. PLOS Pathogens, In Press
  3. Minami S, Nouda R, Hirai K, Chen Z, Kotaki T, Kanai Y, Kobayashi T. Establishment of reverse genetics systems for Colorado tick fever virus.PLoS Pathog. 2025 Feb 14;21(2):e1012921. doi: 10.1371/journal.ppat.1012921. eCollection 2025 Feb. PMID: 39951465
  4. Kamon M, Wakatsuki S, Nakamori M, Takahashi MP, Mori-Yoshimura M, Komaki H, Araki T. Identification of ZNF850 as a novel CTG repeat expansion-related gene in myotonic dystrophy type 1 patient-derived iPSCs. Hum Mol Genet. 2025 Feb 8;34(4):327-337. doi: 10.1093/hmg/ddae186.
  5. Du X, Nakanishi H, Yamada T, Sin Y, Minegishi K, Motohashi N, Aoki Y, Itaka K. Polyplex Nanomicelle-Mediated Pgc-1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice. Adv Sci (Weinh). 2025 Apr;12(16):e2409065. doi: 10.1002/advs.202409065.
  6. Nakanishi H, Itaka K. Extracellular ligand-responsive translational regulation of synthetic mRNAs using engineered receptors. NPG Asia Materials. 2025 17: 25. https://doi.org/10.1038/s41427-025-00607-6
  7. Nagaoka K, Nakanishi H, Tanaka H, Anindita J, Kawamura T, Tanaka T, Yamashita T, Kuroda A, Nomura S, Akita H, Itaka K, Kodama T, Kakimi K. Neoantigen mRNA vaccines induce progenitor-exhausted T cells that support anti-PD-1 therapy in gastric cancer with peritoneal metastasis. Gastric Cancer. 2025 Sep;28(5):825-836. doi: 10.1007/s10120-025-01640-8.
  8. Terai Y, Yada E, Nakanishi H, Itaka K. mRNA-Based Combination Therapy for Inflammation-Driven Osteoarthritis Induced by Monosodium Iodoacetate. Pharmaceutics.17(10): 1254, 2025 10.3390/pharmaceutics17101254
  9. Inagaki S, Kondo Y, Religia P, Adhitama N, Kato Y, Watanabe E, Watanabe H. Application of deep learning for evaluation of the growth rate of Daphnia magna. J Biosci Bioeng. 2025 May;139(5):384-391. doi: 10.1016/j.jbiosc.2025.01.006. Epub 2025 Feb 17. PMID: 39955201.
  10. Leim J, Adhitama N, Nong QD, Religia P, Kato Y, Watanabe H. HP1-Mediated Silencing of the Doublesex1 Gene for Female Determination in the Crustacean Daphnia magna. J Dev Biol. 2025 Jul 3;13(3):23. doi: 10.3390/jdb13030023. PMID: 40700141; PMCID: PMC12286036.
  11. Kato Y, Watanabe H. Crosstalk between environmental factors and sex determination pathway: insights from lepidopteran insects and cladoceran crustaceans. Curr Opin Insect Sci. 2025 Oct;71:101403. doi: 10.1016/j.cois.2025.101403. Epub 2025 Jun 19. PMID: 40543842.
  12. Larrea E, Tellaetxe-Abete M, Peng Y, Zhang Y, Feng S, Lu K, Xue L, Nakahama T, Kawahara Y, Koziol MJ. RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond. Scientific Reports, 16(1): 451, 2025.
  13. Ryo Yanagiya, So Nakagawa, Makoto Onizuka, Ai Kotani. Aberrant expression of human endogenous retrovirus K9-derived elements is associated with better clinical outcome of acute myelocytic leukemia. Retrovirology. 2025 Apr 1;22(1):4. doi: 10.1186/s12977-025-00661-6.
  14. Ryo Yanagiya, Hiroko Kato, Akinori Ninomiya, Masaya Ueno, Akane Kanamori, Yuji Miyatake, Masahiro Oka, Keisuke Ishii, Tadashi Matsuura, So Nakagawa, Atsushi Hirao, Makoto Onizuka, Ai Kotani. Revised model for cell cycle regulation by iron: differential roles between transferrin and ferritin. Redox Biol. 2025 Jun 11:85:103727. doi: 10.1016/j.redox.2025.103727. Online ahead of print.
  15. Osawa T, Miyata K, Ito S, Uda K, Obika S. Regulation of Duplex Formation in Response to pH and Complementary RNA: Development of Oligonucleotides Modified with S‑Methylthioimidate-Bridged Nucleic Acid and Evaluation of Their Function. ACS Omega. 2025 Dec 22;11(2):3436-3447. doi: 10.1021/acsomega.5c10817.”
  16. Kuroda T, Yoshioka K, Mon SSL, Katsuyama M, Sato K, Isogai E, Yoshida-Tanaka K, Iwata-Hara R, Yamaguchi T, Obika S, Yokota T. Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications. Mol Ther Nucleic Acids. 2025 Sep 12;36(4):102692. doi: 10.1016/j.omtn.2025.102692.
  17. Hinata D, Kai Y, Fukuda R, Kamada Y, Kasahara Y, Sasaki K, Yoshida T, Obika S, Inoue T, Okiyoneda T. Antisense oligonucleotide targeting the E3 ligase RFFL potentiates CFTR modulator efficacy in CF primary bronchial epithelial cells. Mol Ther Nucleic Acids. 2025 Oct 31;36(4):102756. doi: 10.1016/j.omtn.2025.102756.
  18. Kumagai R, Yamada R, Yamaguchi T, Obika S. Development of Synthetic Routes to 2′-O,4′-C-Spirocyclopentylene-Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine. Chemistry. 2025 Dec 12;31(70):e02995. doi: 10.1002/chem.202502995.
  19. Yamaguchi T, Komine H, Sugiura T, Kumagai R, Yoshida T, Sasaki K, Nakayama T, Kamada H, Inoue T, Obika S. Cycloalkane Incorporation Into the 2′,4′-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides. JACS Au. 2025 Oct 15;5(10):5111-5120. doi: 10.1021/jacsau.5c01005.
  20. Tani M, Hatano K, Ishizuya Y, Oka T, Kanaki T, Inoguchi S, Yoshimura A, Horibe Y, Liu Y, Nesrine S, Okuda Y, Yamamoto A, Uemura T, Yamamichi G, Hayashi T, Yamamoto Y, Kato T, Kawashima A, Yamaguchi T, Obika S, Yusa K, Nonomura N, Nimura K. Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer. Cancer Sci. 2025 Dec;116(12):3403-3416. doi: 10.1111/cas.70194.
  21. Hino N, Takada R, Suzuki K, Tokunoh N, Karaki T, Ohtake K, Ogami H, Nishiura T, Ishimoto K, Tsukamoto T, Ago Y, Okada Y, Okamoto T, Ono C, Matsuura Y, Obika S, Sakamoto K, Yoshioka Y, Nakagawa S. Rational design of a covalent ACE2 decoy receptor that broadly neutralizes SARS-CoV-2 variants. Protein Sci. 2025 Oct;34(10):e70306. doi: 10.1002/pro.70306.
  22. Chiba K, Yoshida T, Okada K, Ishikawa M, Hashimoto Y, Obika S, Yamaguchi T. Phthalimide: a potential warhead for switchable and bioorthogonal conjugation. Chem Commun (Camb). 2025 Aug 28;61(71):13417-13420. doi: 10.1039/d5cc03171k.
  23. Shimo T, Obika S. Optimization of 2′,4′-BNA/LNA-Based Oligonucleotides for Splicing Modulation in Vitro. Methods Mol Biol. 2025;2964:361-377. doi: 10.1007/978-1-0716-4730-1_24.
  24. Sowa N, Horie T, Ide Y, Baba O, Kora K, Yoshida T, Nakamura Y, Matsumura S, Matsushita K, Imanaka M, Zou F, Kume E, Kojima H, Qian Q, Kimura K, Otsuka R, Hara N, Yamasaki T, Otani C, Tsujisaka Y, Takaya T, Nishimura C, Watanabe D, Hasegawa K, Kotera J, Oka K, Fujita R, Takemiya A, Sasaki T, Kasahara Y, Obika S, Kimura T, Ono K. MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration. EMBO Mol Med. 2025 Aug;17(8):1902-1925. doi: 10.1038/s44321-025-00273-9.
  25. Hara T, Meng S, Kasahara Y, Osawa T, Motooka D, Sato H, Arao Y, Saito Y, Inoue K, Hamano Y, Doki Y, Eguchi H, Obika S, Ishii H. Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects. Mol Ther Nucleic Acids. 2025 Apr 29;36(2):102548. doi: 10.1016/j.omtn.2025.102548.
  26. Osawa T, Nakanishi R, Uda K, Muramoto S, Obika S. Synthesis and structural analysis of dinucleotides containing 2′,3′-trans-bridged nucleic acids with trans-5,6- or 5,7-fused ring skeleton.Commun Chem. 2025 Mar 22;8(1):87. doi: 10.1038/s42004-025-01486-2.
  27. Shimo T, Hasegawa J, Yoshioka K, Nakatsuji Y, Aso K, Tachibana K, Nagata T, Yokota T, Obika S. Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides. Mol Ther Nucleic Acids. 2025 Feb 1;36(1):102468. doi: 10.1016/j.omtn.2025.102468.”
  28. Hayashida M, Suzuki R, Horie S, Masuda J, Yamaguchi T, Obika S. Separation of deaminated impurities from the desired oligonucleotides using supercritical fluid chromatography. J Chromatogr A. 2025 Mar 15;1744:465731. doi: 10.1016/j.chroma.2025.465731.
  29. Kusumoto K, Sasaki K, Uchida Y, Utsumi A, Yoshida T, Obika S, Inoue T, Okuhira K. Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides. Sci Rep. 2025 Jan 2;15(1):586. doi: 10.1038/s41598-024-84310-6.
  30. Poonperm R, Yoneda T, Imada T, Takahashi S, Ichinose T, Miura H, Hayashi T, Kuse M, Yoshimura M, Nagao K, Obuse C, Nikaido I, Hiratani I, Takebayashi SI. scRepli-RamDA-seq: a multi-omics technology enabling the analysis of gene expression dynamics during S-phase. Nat Commun. 2025 Dec 15;16(1):10902. doi: 10.1038/s41467-025-64688-1. PMID: 41397953″
  31. Zhu X, Bektash A, Hatoyama Y, Muramatsu S, Isobe SY, Obuse C, Toyoda A, Daigaku Y, Chen CL, Kanemaki MT. Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication. Nat Commun. 2025 Dec 2;16(1):10069. doi: 10.1038/s41467-025-66278-7. PMID: 41331242″
  32. Obuse C, Nakayama JI. Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin. Biochim Biophys Acta Gen Subj. 2025 May;1869(6):130790. doi: 10.1016/j.bbagen.2025.130790. Epub 2025 Mar 6. PMID: 40057003 “
  33. Asakawa H, Nagao K, Fukagawa T, Obuse C, Hiraoka Y, Haraguchi T. Interaction mapping between nucleoporins in the fission yeast Schizosaccharomyces pombe using mass-spectrometry. J Biochem. 2025 Apr 2;177(4):273-286. doi: 10.1093/jb/mvae095. PMID: 39727334″
  34. Kotaki T, Akieda Y, Chen Z, Onishi M, Komatsu S, Motooka D, Omori H, Tamiya S, Kanai Y, Minami S, Kawagishi T, Sakon N, Sato S, Ishitani T, Kobayashi T. Recovery of infectious recombinant human norovirus using zebrafish embryos. Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2526726122. doi: 10.1073/pnas.2526726122. Epub 2025 Dec 4. PMID: 41343680 “
  35. Kotaki T, Kanai Y, Ogden KM, Onishi M, Kumthip K, Khamrin P, Boonyos P, Phoosangwalthong P, Singchai P, Luechakham T, Minami S, Chen Z, Hirai K, Tacharoenmuang R, Mizushima H, Ushijima H, Maneekarn N, Kobayashi T. A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection. mBio. 2025 Jul 9;16(7):e0089725. doi: 10.1128/mbio.00897-25. Epub 2025 May 30. PMID: 40444468″
  36. Kotaki T, Kanai Y, Onishi M, Sakai Y, Motooka D, Chen Z, Enoki Y, Komatsu S, Hirai K, Minami S, Kawagishi T, Ushijima H, Kobayashi T. Single-round infectious rotaviruses with deletions of VP7 or VP4 genes, based on SA11 and WC3 strain backbones, and their potential use as viral vectors. PLoS Pathog. 2025 Sep 15;21(9):e1013484. doi: 10.1371/journal.ppat.1013484. eCollection 2025 Sep. PMID: 40953082″
  37. Yano K, Takashima T, Feng Z, Kohara M, Nagata H, Okuzaki D, Shintani Y, Morii E. Investigating the Role of Long Non-Coding RNA HAGLR and Its Target NT5E in Alveolar Epithelial Injury. Pathol Int. 2025 Dec;75(12):613-623. doi: 10.1111/pin.70067. Epub 2025 Dec 9. PMID: 41362965 “
  38. Takashima T, Zeng C, Murakami E, Fujiwara N, Kohara M, Nagata H, Feng Z, Sugai A, Harada Y, Ichijo R, Okuzaki D, Nojima S, Matsui T, Shintani Y, Kawai G, Hamada M, Hirose T, Nakatani K, Morii E. Involvement of lncRNA MIR205HG in idiopathic pulmonary fibrosis and IL-33 regulation via Alu elements. JCI Insight. 2025 Mar 10;10(5):e187172. doi: 10.1172/jci.insight.187172. PMID: 40059822″
  39. Fukumoto A, Yamanaka T, Yanaizu M, Nakamori M, Hama M, Yasumizu Y, Shiotsu K, Matsumura T, Nutter CA, Kubota T, Fujimura H, Kino Y, Swanson MS, Inoue K, Takahashi MP.Transcriptome alterations underlying metabolic dysfunction and liver disease in myotonic dystrophy type 1. Hum Mol Genet. 2025 Oct 5;34(20):1718-1732. doi: 10.1093/hmg/ddaf124.
  40. Maeno S, Yamashita A, Oie Y, Koto R, Kai C, Nishida N, Nakamori M, Tsujikawa M, Nishida K.Repeat Expansion and Somatic Instability in TCF4 in Patients With Fuchs Endothelial Corneal Dystrophy Identified by Small Pool PCR. Invest Ophthalmol Vis Sci. 2025 Aug 1;66(11):14. doi: 10.1167/iovs.66.11.14.”
  41. Shimizu F, Koga M, Mizukami Y, Watanabe K, Sato R, Takeshita Y, Maeda T, Kanda T, Nakamori M.Small Nuclear Ribonucleoprotein Autoantibody Associated With Blood-Nerve Barrier Breakdown in Guillain-Barré Syndrome. Neurol Neuroimmunol Neuroinflamm. 2025 Jul;12(4):e200405.
  42. Imai T, Miyai M, Nemoto J, Tamai T, Ohta M, Yagi Y, Nakanishi O, Mochizuki H,Pentatricopeptide repeat protein targeting CUG repeat RNA ameliorates RNA toxicity in a myotonic dystrophy type 1 mouse model. Nakamori M. Sci Transl Med. 2025 Apr 16;17(794):eadq2005. doi: 10.1126/scitranslmed.adq2005
  43. Kawakami Y, Iguchi Y, Li J, Amakusa Y, Yoshimura T, Chikuchi R, Yokoi S, Iida M, Riku Y, Iwasaki Y, Hirose T, Nakagawa S, Katsuno M. Downregulation of NEAT1 due to loss of TDP-43 function exacerbates motor neuron degeneration in amyotrophic lateral sclerosis. Brain Commun. 2025 Jul 2;7(4):fcaf261. doi: 10.1093/braincomms/fcaf261. eCollection 2025.
  44. Hirose T, Fujiwara N, Ninomiya K, Yamamoto T, Nakagawa S, Yamazaki T. Architectural RNAs: blueprints for functional membraneless organelle assembly. Trends Genet. 2025 Oct;41(10):919-933. doi: 10.1016/j.tig.2025.05.007.
  45. Fujiwara N, Ueno T, Yamazaki T, Hirose T. Unraveling architectural RNAs: Structural and functional blueprints of membraneless organelles and strategies for genome-scale identification. Biochim Biophys Acta Gen Subj. 2025 Jul;1869(8):130815. doi: 10.1016/j.bbagen.2025.130815.
  46. Yamamoto T, Yamazaki T, Ninomiya K, Nakagawa S, Hirose T. Biophysical Aspect of Assembly and Regulation of Nuclear Bodies Scaffolded by Architectural RNA. J Mol Biol. 2025 May 1;437(9):169016. doi: 10.1016/j.jmb.2025.169016.
  47. Takakuwa H, Hirose T. Speckle signatures dictate cancer prognosis. Nat Cell Biol. 2025 Feb;27(2):180-181. doi: 10.1038/s41556-024-01569-7.

2024

  1. Ukon K, Nojima S, Motooka D, Takashima T, Kohara M, Kiyokawa H, Kimura K, Fukui E, Tahara S, Kido K, Matsui T, Shintani Y, Okuzaki D, Morii E.  Spatial transcriptome analysis of lung squamous cell carcinoma arising from interstitial pneumonia provides insights into tumor heterogeneity.Pathol Res Pract.2025 Feb;266:155805. doi: 10.1016/j.prp.2024.155805. Epub 2024 Dec 31. PMID: 39756106
  2. Tahara S, Sato K, Kido K, Morii E.Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis. Pathol Res Pract. 2025 Feb;266:155804. doi: 10.1016/j.prp.2024.155804. Epub 2024 Dec 30. PMID: 39753019
  3. Umeda D, Harada A, Motooka D, Tahara S, Kurashige M, Kido K, Takashima T, Kiyokawa H, Ukon K, Matsui T, Matsumoto S, Shintani Y, Okuzaki D, Kikuchi A, Nojima S, Morii E. Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α.Sci Rep. 2024 Dec 30;14(1):31642. doi: 10.1038/s41598-024-80280-x. PMID: 39738173
  4. Suyama R, Kai T.piRNA processing within non-membrane structures is governed by constituent proteins and their functional motifs.FEBS J. 2024 Dec 30. doi: 10.1111/febs.17360. Online ahead of print.PMID: 39739617 Review.
  5. Asakawa H, Nagao K, Fukagawa T, Obuse C, Hiraoka Y, Haraguchi T.Interaction mapping between nucleoporins in the fission yeast Schizosaccharomyces pombe using mass-spectrometry.J Biochem. 2024 Dec 27:mvae095. doi: 10.1093/jb/mvae095. Online ahead of print.
  6. Sangkuanun T, Tipbunjong C, Kato Y, Watanabe H, Peerakietkhajorn S. Dragon fruit-derived oligosaccharides alter hemocyte-mediated immunity and expression of genes related to innate immunity and oxidative stress in Daphnia magna. Dev Comp Immunol. 2024 Dec;161:105251. doi: 10.1016/j.dci.2024.105251.
  7. Kanai Y, Kotaki T, Sakai S, Ishisaka T, Matsuo K, Yoshida Y, Hirai K, Minami S, Kobayashi T.Rapid production of recombinant rotaviruses by overexpression of NSP2 and NSP5 genes with modified nucleotide sequences. J Virol. 2024 Dec 17;98(12):e0099624. doi: 10.1128/jvi.00996-24. Epub 2024 Nov 4.
  8. Honda M, Shimizu F, Sato R, Nakamori M. Contribution of Complement, Microangiopathy and Inflammation in Idiopathic Inflammatory Myopathies. J Neuromuscul Dis. 2024;11(1):5-16. doi: 10.3233/JND-230168.
  9. Shimizu R, Sakamoto J, Adhitama N, Fujikawa M, Religia P, Kamei Y, Watanabe H, Kato Y. Spatiotemporal control of transgene expression using an infrared laser in the crustacean Daphnia magna. Sci Rep. 2024 Oct 28;14(1):25696. doi: 10.1038/s41598-024-77458-8.
  10. Suzuki N, Mori-Yoshimura M, Katsuno M, Takahashi MP, Yamashita S, Oya Y, Hashizume A, Yamada S, Nakamori M, Izumi R, Kato M, Warita H, Tateyama M, Kuroda H, Asada R, Yamaguchi T, Nishino I, Aoki M. Safety and efficacy of aceneuramic acid in GNE myopathy: open-label extension study. J Neurol Neurosurg Psychiatry. 2024 Oct 16;95(11):1093-1094. doi: 10.1136/jnnp-2024-333853.
  11. Ichiro Taniguchi , Tetsuro Hirose , Mutsuhito Ohno.The RNA helicase DDX39 contributes to the nuclear export of spliceosomal U snRNA by loading of PHAX onto RNA.Nucleic Acids Research.2024 Sep 23;52(17):10668-10682. doi: 10.1093/nar/gkae622.
  12. Santos JL, Nick F, Adhitama N, Fields PD, Stillman JH, Kato Y, Watanabe H, Ebert D. Trehalose mediates salinity-stress tolerance in natural populations of a freshwater crustacean. Curr Biol. 2024 Sep 23;34(18):4160-4169.e7. doi: 10.1016/j.cub.2024.07.082.
  13. Hicks SM, Frias JA, Mishra SK, Scotti M, Muscato DR, Valero MC, Adams LM, Cleary JD, Nakamori M, Wang E, Berglund JA. Alternative splicing dysregulation across tissue and therapeutic approaches in a mouse model of myotonic dystrophy type 1. Mol Ther Nucleic Acids. 2024 Sep 13;35(4):102338. doi: 10.1016/j.omtn.2024.102338.
  14. Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern.
    Tahara S, Nojima S, Takashima T, Okuzaki D, Morii E. Pathol Res Pract. 2024 Oct;262:155562. doi: 10.1016/j.prp.2024.155562. Epub 2024 Aug 24. PMID: 39182448
  15. Manisha Yadav, Rachel J Harding, Tiantian Li, Xin Xu, Terence Gall-Duncan, Mahreen Khan, Costanza Ferrari Bardile, Glen L Sequiera, Shili Duan, Renu Chandrasekaran, Anni Pan, Jiachuan Bu, Tomohiro Yamazaki, Tetsuro Hirose, Panagiotis Prinos, Lynette Tippett, Clinton Turner, Maurice A Curtis, Richard L M Faull, Mahmoud A Pouladi, Christopher E Pearson, Housheng Hansen He, Cheryl H Arrowsmith.Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles.Science Advances.10.1126/sciadv.ado5264
  16. Fengmei Xu,Ritsuko Suyama,Toshifumi Inada,Shinichi Kawaguchi ,Toshie Kai .HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis.Development (2024) 151 (14):dev202795.16 JULY 2024doi:10.1242/dev.202795 .Epub 2024 Jul 16.PMID: 38881530
  17. Kamakura T, Kameda K, Manabe M, Torii K, Sugiura Y, Ito S, Nakayama S, Shimizu T, Nagashima E, Kamiya K, Oka M, Tanaka M, Otsuka M, Ohtsuka M, Kotani A.　 PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation. Cell Death Discov. 2024 Jul 12;10(1):322. doi: 10.1038/s41420-024-02080-6.
  18. Yanagiya R, Miyatake Y, Watanabe N,Shimizu T,Kanamori A,Ueno M,Okabe S,Carreras J, Nakayama S,Hasegawa A,Kameda K,Nakagawa S,Yamauchi T,Maeda T,Ishii K,Matsuura T,Handa H, Hirao A,Ishizawa K,Onizuka M,Mashima T,Nakamura N,Ando K, Kotani A. Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia.Leukemia 2024 Aug; 38(8):1731-1741. doi: 10.1038/s41375-024-02296-6. Epub 2024 Jun 24.
  19. Generation of single-round infectious rotavirus with a mutation in the intermediate capsid protein VP6.
    Kotaki T, Kanai Y, Onishi M, Minami S, Chen Z, Nouda R, Nurdin JA, Yamasaki M, Kobayashi T. J Virol. 2024 Jul 23;98(7):e0076224. doi: 10.1128/jvi.00762-24. Epub 2024 Jun 5.
  20. Manisha Yadav, Rachel J Harding, Tiantian Li, Xin Xu, Terence Gall-Duncan, Mahreen Khan, Costanza Ferrari Bardile, Glen L Sequiera, Shili Duan, Renu Chandrasekaran, Anni Pan, Jiachuan Bu, Tomohiro Yamazaki, Tetsuro Hirose, Panagiotis Prinos, Lynette Tippett, Clinton Turner, Maurice A Curtis, Richard L M Faull, Mahmoud A Pouladi, Christopher E Pearson, Housheng Hansen He, Cheryl H Arrowsmith.Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles.Science Advances.10.1126/sciadv.ado5264
  21. Kohashi H, Nagata R, Tamenori Y, Amatani T, Ueda Y, Mori Y, Kasahara Y, Obika S, Shimojo M. A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides. Nucleic Acids Res. 2024, 52(9):4784-4798. doi: 10.1093/nar/gkae245. PMID: 38621757; PMCID: PMC11109983.
  22. Yoshida T, Hagihara T, Uchida Y, Horiuchi Y, Sasaki K, Yamamoto T, Yamashita T, Goda Y, Saito Y, Yamaguchi T, Obika S, Yamamoto S, Inoue T. Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation. Sci Rep. 2024 May 21;14(1):11540. doi: 10.1038/s41598-024-61666-3. PMID: 38773176; PMCID: PMC11109122.
  23. Hashizume M, Takashima A, Iwasaki M. An mRNA-LNP-based Lassa virus vaccine induces protective immunity in mice. J Virol. 2024 May 20:e0057824. doi: 10.1128/jvi.00578-24. PMID: 38767352.
  24. Kudo K,Yanagiya R,Hasegawa M,Carreras J,Miki Y,Nakayama S,Nagashima E,Miyatake Y,Torii K, Ando K,Nakamura N,Miyajima A,Murakami M,Kotani A.Unique lipid composition maintained by extracellular blockade leads to prooncogenicity. Cell Death and Discov. 2024,221.2024 May 8;10(1):221. doi: 10.1038/s41420-024-01971-y.
  25. Hikaru Toya, Yuko Okamatsu-Ogura, Saori Yokoi, Misuzu Kurihara, Mari Mito, Shintaro Iwasaki, Tetsuro Hirose, Shinichi Nakagawa.The essential role of architectural noncoding RNA Neat1 in cold-induced beige adipocyte differentiation in mice.RNA.10.1261/rna.079972.124
  26. Huo W, Miki K, Mu H, Osawa T, Yamaguma H, Kasahara Y, Obika S, Kawaguchi Y, Hirose H, Futaki S, Miyazaki Y, Shinoda W, Akai S, Ohe K. Light-controllable cell-membrane disturbance for intracellular delivery. J Mater Chem B. 2024 May, 1;12(17):4138-4147. doi: 10.1039/d3tb02956e. PMID: 38456552
  27. Kato Y, Nitta JH, Perez CAG, Adhitama N, Religia P, Toyoda A, Iwasaki W, Watanabe H. Identification of gene isoforms and their switching events between male and female embryos of the parthenogenetic crustacean Daphnia magna.Sci Rep. 2024 Apr 30;14(1):9407. doi: 10.1038/s41598-024-59774-1.
  28. Hoshino H, Kasahara Y, Obika S. Polyamines promote xenobiotic nucleic acid synthesis by modified thermophilic polymerase mutants. RSC Chem Biol. 2024, ;5(5):467-472. doi: 10.1039/d4cb00017j. PMID: 38725908; PMCID: PMC11078213.
  29. Matsubayashi T, Yoshioka K, Lei Mon SS, Katsuyama M, Jia C, Yamaguchi T, Hara RI, Nagata T, Nakagawa O, Obika S, Yokota T. Erratum: Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′ -BNA/LNA with 9-(aminoethoxy)phenoxazine. Mol Ther Nucleic Acids. 2024, 35(2):102182. doi: 10.1016/j.omtn.2024.102182. Erratum for: doi: 10.1016/j.omtn.2024.102161. PMID: 38590918; PMCID: PMC10999694.
  30. Wariishi T, Kataoka Y, Nakamura T, Kasahara Y, Kuroda M, Obika S, Kuwahara M. Lantern-type G-quadruplex fluorescent sensors for detecting divalent metal ions, Anal Biochem. 2024 Jul;690:115525. doi:10.1016/j.ab.2024.115525. Epub 2024 Mar 28. PMID: 38554995.
  31. Togawa H, Okubo T, Horiuchi K, Yamaguchi T, Tomita-Sudo E, Akita T, Kawakami J, Obika S. Separation of the diastereomers of phosphorothioated siRNAs by anion-exchange chromatography under non-denaturing conditions. J Chromatogr A. 2024, 1721:464847. doi: 10.1016/j.chroma.2024.464847. Epub 2024 Mar 25. PMID: 38552370.
  32. Shohei Minami,Tomohiro Kotaki,Yusuke Sakai,Shinya Okamura,Shiho Torii,Chikako Ono,Daisuke Motooka,Rina Hamajima,Ryotaro Nouda,Jeffery A Nurdin,Moeko Yamasaki,Yuta Kanai,Hirotaka Ebina,Yusuke Maeda,Toru kamoto,Taro Tachibana,Yoshiharu Matsuura,Takeshi Kobayashi. Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage. Microbiol Spectr. 2024 Apr 2;12(4):e0285923.
    doi: 10.1128/spectrum.02859-23. Epub 2024 Feb 28.
  33. Lanlan Bai,Tetsuya Tani,Takeshi Kobayashi,Ryotaro Nouda,Yuta Kanai,Yusuke Sano,Kazutoshi Takami,Hiroshi Tomita,Eriko Sugano,Taku Ozaki,Tohru Kiyono,Tomokazu Fukuda. Establishment of immortalized Egyptian Rousettus bat cell lines. FEBS Open Bio. 2024 Apr;14(4):598-612. doi: 10.1002/2211-5463.13781. Epub 2024 Feb 19.
  34. Osawa T, Obika S. Synthesis of Coumarin-Conjugated Oligonucleotides via Knoevenagel Condensation to Prepare an Oligonucleotide Library. Chem Pharm Bull (Tokyo). 2024;72(2):143-148. doi: 10.1248/cpb.c23-00295. PMID: 38296555.
  35. Yum J, Aulia F, Kamiya K, Hori M, Qiao N, Kim BS, Naito M, Ogura S, Nagata T, Yokota T, Uchida S, Obika S, Kim HJ, Miyata K. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjug Chem. 2024 Feb 21;35(2):125-131. doi: 10.1021/acs.bioconjchem.3c00456. Epub 2024 Jan 30. PMID: 38290165.
  36. Kurashige R, Kurashige M, Okada Y, Higuchi K, Yuda S, Hino A, Miyamura T, Ichii M, Fukushima K, Honma K, Takeuchi M, Yokota T, Ishikawa J, Sawada A, Shibayama H, Hosen N, Morii E. Differentiating Between Epstein-Barr Virus-positive Lymphoid Neoplasm Relapse and Post-transplant Lymphoproliferative Disorder After Sex-mismatched Hematopoietic Stem Cell Transplantation.Am J Surg Pathol. 2024 Apr 1;48(4):395-405. doi: 10.1097/PAS.0000000000002183. Epub 2024 Jan 30.
  37. Yoshinori Shirasaka,Kentaro Yamada,Tsuyoshi Etoh,Kazuko Noguchi,Takumi Hasegawa,Katsuhiro Ogawa,Takeshi Kobayashi,Akira Nishizono,Masafumi Inomata, Cytocidal Effect of Irradiation on Gastric Cancer Cells Infected with a Recombinant Mammalian Orthoreovirus Expressing a Membrane-Targeted KillerRed. Pharmaceuticals (Basel). 2024 Jan 8;17(1):79. doi: 10.3390/ph17010079.
  38. Osawa T, Akino T, Obika S. Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid. J Org Chem. 2024 Jan 5;89(1):269-280. doi: 10.1021/acs.joc.3c02019.

2023

  1. Mahana Y, Ariyoshi M, Nozawa RS, Shibata S, Nagao K, Obuse C, Shirakawa M.Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46.
    Structure. 2024 Mar 7;32(3):304-315.e5. doi: 10.1016/j.str.2023.12.001. Epub 2023 Dec 29.PMID: 38159574
  2. Nakamori M, Nakatani D, Sato T, Hasuike Y, Kon S, Saito T, Nakamura H, Takahashi MP, Hida E, Komaki H, Matsumura T, Takada H, Mochizuki H. Erythromycin for myotonic dystrophy type 1: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. EClinicalMedicine. 2023 Dec 26;67:102390. doi: 10.1016/j.eclinm.2023.102390.
  3. Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways.Commun Biol.Ritsuko Suyama, Nicolas Cetraro, Joanne Y Yew, Toshie Kai.2023 Dec 20;6(1):1287. doi:10.1038/s42003-023-05660-x.
  4. Osawa T, Akino T, Obika S. Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid. J Org Chem. 2024, 89(1):269-280. doi: 10.1021/acs.joc.3c02019. Epub 2023 Dec 8. PMID: 38064209.
  5. Ishida K, Kasahara Y, Hoshino H, Okuda T, Obika S. Systematic Analysis of 2′-O-Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties. Molecules. 2023 Dec 2;28(23):7911. doi: 10.3390/molecules28237911.
  6. Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles.Nat Cell Biol. Hiro Takakuwa , Tomohiro Yamazaki , Sylvie Souquere , Shungo Adachi , Hyura Yoshino , Naoko Fujiwara , Tetsuya Yamamoto , Tohru Natsume , Shinichi Nakagawa , Gerard Pierron , Tetsuro Hirose .2023 Nov;25(11):1664-1675. doi: 10.1038/s41556-023-01254-1
  7. Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors. Ayana Suzuki , Satoshi Nojima, Shinichiro Tahara , Daisuke Motooka, Masaharu Kohara, Daisuke Okuzaki, Mitsuyoshi Hirokawa, Eiichi Morii. J Pathol Transl Med. 2024 Jan;58(1):22-28. DOI: 10.4132/jptm.2023.11.21
  8. Hayashida M, Suzuki R, Horie S, Masuda J, Yamaguchi T, Obika S. Applicabilityof supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study.  J Chromatogr A. 2023 Oct 11;1708:464333. doi:10.1016/j.chroma.2023.464333.
  9. Functional domains of nuclear long noncoding RNAs: Insights into gene regulation and intracellular architecture.Obuse C, Hirose T.Curr Opin Cell Biol. 2023 Oct 6;85:102250. doi: 10.1016/j.ceb.2023.102250.
  10. Analysis of splicing abnormalities in the white matter of myotonic dystrophy type 1 brain using RNA sequencing.
    Yoshizumi K, Nishi M, Igeta M, Nakamori M, Inoue K, Matsumura T, Fujimura H, Jinnai K, Kimura T. Neurosci Res. 2023 Oct 6:S0168-0102(23)00192-X. doi:10.1016/j.neures.2023.10.002. Online ahead of print. PMID: 37806497
  11. Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
    Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE. Cell. 2023 Oct 5:S0092-8674(23)01030-9. doi:10.1016/j.cell.2023.09008

  12. Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis.Yuxuan Lin, Ritsuko Suyama, Shinichi Kawaguchi, Taichiro Iki, Toshie Kai. The Journal of cell biology 222(10) 2023 Oct 2 DOI: 10.1083/jcb.202303125

  13. Yuta Kanai,Misa Onishi,Yukino Yoshida,Tomohiro Kotaki,Shohei Minami,Ryotaro Nouda,Moeko Yamasaki,Yasutaka Enoki,Takeshi Kobayashi. Genetic engineering strategy for generating a stable dsRNA virus vector using a virus-like codon-modified transgene. J Virol. 2023 Sep 21:e0049223. doi: 10.1128/jvi.00492-23. Online ahead of print.

  14. Tumor heterogeneity from the viewpoint of pathologists.Morii E. Pathol Int. 2023 Sep;73(9):394-405. doi: 10.1111/pin.13366. Epub 2023 Aug 28. PMID: 37638598 Review.
  15. Takuya Kubo,Eisuke Kanao,Koki Ishida,Shohei Minami,Tetsuya Tanigawa,Ryosuke Mizuta,Yoshihiro Sasaki,Koji Otsuka,Takeshi Kobayashi. Efficient Selective Adsorption of SARS-CoV-2 via the Recognition of Spike Proteins Using an Affinity Spongy Monolith. Anal Chem. 2023 Sep 5;95(35):13185-13190. doi: 10.1021/acs.analchem.3c02097. Epub 2023 Aug 23.
  16. Replication dynamics identifies the folding principles of the inactive X chromosome.Poonperm R, Ichihara S, Miura H, Tanigawa A, Nagao K, Obuse C, Sado T, Hiratani I.  Nat Struct Mol Biol. 2023 Aug;30(8):1224-1237. doi: 10.1038/s41594-023-01052-1.
  17. Mikami A, Mori S, Osawa T, Obika S. Post-Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex-Forming Ability. Chemistry. 2023 Aug 27:e202301928. doi: 10.1002/chem.202301928.
  18. Yamaguchi T, Horie N, Aoyama H, Kumagai S, Obika S. Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N’- methylguanidine-bridged nucleic acids.Nucleic Acids Res. 2023 Aug 25;51(15):7749-7761. doi: 10.1093/nar/gkad608.
  19. Deep Learning-Based Differential Diagnosis of Follicular Thyroid Tumors Using Histopathological Images.
    Nojima S, Kadoi T, Suzuki A, Kato C, Ishida S, Kido K, Fujita K, Okuno Y, Hirokawa M, Terayama K, Morii E. Mod Pathol. 2023 Jul 31;36(11):100296. doi: 10.1016/j.modpat.2023.100296. Online ahead of print. PMID: 37532181
  20. Miyake K, Costa Cruz PH, Nagatomo I, Kato Y, Motooka D, Satoh S, Adachi Y, Takeda Y, Kawahara Y, Kumanogoh A. A cancer-associated METTL14 mutation induces aberrant m6A modification affecting tumor growth. Cell Rep. 2023 Jul 25;42(7):112688. doi: 10.1016/j.celrep.2023.112688.
  21. Taichiro Iki,Shinichi Kawaguchi,Toshie Kai. miRNA/siRNA-directed pathway to produce noncoding piRNAs from endogenous protein-coding regions ensures Drosophila spermatogenesis. Science Advances.  2023 July 21;9(29):eadh0397. doi: 10.1126/sciadv.adh0397
  22. Chao Zeng , Takeshi Chujo , Tetsuro Hirose , Michiaki Hamada . Landscape of semi-extractable RNAs across five human cell lines. Nucleic Acids Research. 19 July 2023. doi:10.1093/nar/gkad567
  23. Shohei Minami,Naomi Matsumoto,Hiroko Omori,Yutaka Nakamura,Shigeyuki Tamiya,Ryotaro Nouda,Jeffery A Nurdin,Moeko Yamasaki,Tomohiro Kotaki,Yuta Kanai,Toru Okamoto,Taro Tachibana,Hiroshi Ushijima,Takeshi Kobayashi,Shintaro Sato. Effective SARS-CoV-2 replication of monolayers of intestinal epithelial cells differentiated from human induced pluripotent stem cells. Sci Rep. 2023 Jul 18;13(1):11610. doi:0.1038/s41598-023-38548-1.
  24. Chiba K, Yamaguchi T, Obika S. Development of 8-17 XNAzymes that are functional in cells. Chem Sci. 2023 Jun 28;14(28):7620-7629. doi:10.1039/d3sc01928d.
  25. Miyake K, Costa Cruz PH, Nagatomo I, Kato Y, Motooka D, Satoh S, Adachi Y, Takeda Y, Kawahara Y, Kumanogoh A. A cancer-associated METTL14 mutation induces aberrant m6A modification affecting tumor growth. Cell Reports. 2023 in press.Doi:10.1016/j.celrep.2023.112688
  26. Sheikh Ariful Hoque,Tomohiro Kotaki,Ngan Thi Kim Pham,Yuko Onda,Shoko Okitsu,Shintaro Sato,Yoshikazu Yuki,Takeshi Kobayashi,Niwat Maneekarn,Hiroshi Kiyono,Satoshi Hayakawa,Hiroshi Ushijima. Genotype Diversity of Enteric Viruses in Wastewater Amid the COVID-19 Pandemic. Food Environ Virol. 2023 Jun;15(2):176-191. doi: 10.1007/s12560-023-09553-4. Epub 2023 Apr 14.
  27. Ovarian high-grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance.
    Kido K, Nojima S, Motooka D, Nomura Y, Kohara M, Sato K, Ohshima K, Tahara S, Kurashige M, Umeda D, Takashima T, Kiyokawa H, Ukon K, Matsui T, Okuzaki D, Morii E. J Pathol. 2023 May;260(1):56-70. doi: 10.1002/path.6064.
  28. Xing Y, Nakahama T, Wu Y, Inoue M, Kim JI, Todo H, Shibuya T, Kato Y, Kawahara Y. RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing . J Biol Chem. 2023 online ahead of publication. doi: 10.1016/j.jbc.2023.104840.
  29. Kitamura A, Jiayue C, Suwa T, Kato Y, Wada T, Watanabe H. Neonatal administration of synthetic estrogen, diethylstilbestrol to mice up-regulates inflammatory Cxclchemokines located in the 5qE1 region in the vaginal epithelium. PLoS One. 2023 Mar 16;18(3):e0280421. doi: 10.1371/journal.pone.0280421.
  30. Sawamoto H, Sasaki T, Takegawa-Araki T, Utsugi M, Furukawa H, Hirakawa Y, Yamairi F, Kurita T, Murahashi K, Yamada K, Ohta T, Kumagai S, Takemiya A, Obika S, Kotera J, Synthesis and properties of a novel modified nucleic acid, 2′-N-methanesulfonyl-2′-amino-locked nucleic acid, Bioorg Med Chem Lett. 2023 May 15;88:129289. doi: 10.1016/j.bmcl.2023.129289.
  31. Dominant-negative variants in CBX1 cause a neurodevelopmental disorder.
    Kuroda Y, Iwata-Otsubo A, Dias KR, Temple SEL, Nagao K, De Hayr L, Zhu Y, Isobe SY, Nishibuchi G, Fiordaliso SK, Fujita Y, Rippert AL, Baker SW, Leung ML, Koboldt DC, Harman A, Keena BA, Kazama I, Subramanian GM, Manickam K, Schmalz B, Latsko M, Zackai EH, Edwards M, Evans CA, Dulik MC, Buckley MF, Yamashita T, O’Brien WT, Harvey RJ, Obuse C, Roscioli T, Izumi K.Genet Med. 2023 Apr 20:100861. doi: 10.1016/j.gim.2023.100861. Online ahead of print.PMID: 370876352
  32. Takakusa H, Iwazaki N, Nishikawa M, Yoshida T, Obika S, Inoue T, Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs, Nucleic Acid Ther. 2023 Apr;33(2):83-94. doi: 10.1089/nat.2022.0054
  33. Souidi A, Nakamori M, Zmojdzian M, Jagla T, Renaud Y, Jagla K. Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1. EMBO Rep. 2023 Apr 5;24(4):e56616. doi: 10.15252/embr.202256616. Epub 2023 Feb 28.
  34. Nakahama T, Kawahara Y. The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways. Int Immunol. 2023 Mar 14;35(3):123-133. doi: 10.1093/intimm/dxac056.
  35. Tanaka Y, Tanioku Y, Nakayama T, Aso K, Yamaguchi T, Kamada H, Obika S, Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities, Bioorg Med Chem. 2023 Mar 1;81:117192. doi: 10.1016/j.bmc.2023.117192.
  36. Togawa H, Okubo T, Nonaka Y, Yamaguchi T, Obika S, Retention behavior of short double-stranded oligonucleotide and its potential impurities by anion-exchange chromatography under non-denaturing conditions, J Chromatogr A. 2023 Feb 22;1691:463808. doi: 10.1016/j.chroma.2023.463808.
  37. Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.
    Hirano Y, Kinugasa Y, Kubota Y, Obuse C, Haraguchi T, Hiraoka Y.J Biochem. 2023 Feb 17:mvad017. doi: 10.1093/jb/mvad017. Online ahead of print.PMID: 367994443
  38. Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine.
    Morii E, Hatanaka Y, Motoi N, Kawahara A, Hamakawa S, Kuwata T, Nagatomo T, Oda Y, Okamoto A, Tanaka R, Iyoda A, Ichiro M, Matsuo Y, Nakamura N, Nakai T, Fukuhara M, Tokita K, Yamaguchi T, Takenaka M, Kawabata A, Hatanaka KC, Tsubame K, Satoh Y; Working Group on Cytology in the Era of Genomic Medicine. Pathobiology. 2023 Feb 8:1-23. doi: 10.1159/000528346.
  39. Yamasaki M,Kanai Y, Wakamura Y, Kotaki T, Minami S, Nouda R, Jeffery A. N., Kobayashi T. Characterization of Sialic Acid-Independent Simian Rotavirus Mutants in Viral Infection and Pathogenesis. J Virol. 2023 Jan 31;97(1):e01397-22. doi: 10.1128/jvi.01397-22. Epub 2023 Jan 5.
  40. Jeffery A. N., Kotaki T, Kawagishi T, Sato S, Yamasaki M, Nouda R, Minami S, Kanai Y, Kobayashi T. N-glycosylation of rotavirus NSP4 protein affects viral replication and pathogenesis. J Virol. 2023 Jan 31;97(1):e01861-22. doi: 10.1128/jvi.01861-22. Epub 2023 Jan 4.
  41. In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma.
    Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, Sudo T, Kikuta J, Hara T, Motooka D, Liu YC, Okuzaki D, Morii E, Emoto N, Shintani Y, Ishii M. Nat Commun. 2023 Jan 17;14(1):143. doi: 10.1038/s41467-022-35701-8.
  42. Yoshida M, Oda C, Mishima K, Tsuji I, Obika S, Shimojo M, An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells, Cancer Cell Int. 2023 Jan 17;23(1):8. doi: 10.1186/s12935-022-02842-1.
  43. Takegawa-Araki T, Yasukawa K, Iwazaki N, Utsugi M, Furukawa H, Kumagai S, Sawamoto H, Obika S, 2′-N-Alkylaminocarbonyl-2′-amino-LNA: Synthesis, duplex stability, nuclease resistance, and in vitro anti-microRNA activity, Bioorg Med Chem. 2023 Jan 15;78:117148. doi: 10.1016/j.bmc.2022.117148
  44. Rahman Chowdhury T, Taufiq T, Ishida K, Ariful Islam M, Kasahara Y, Osawa T, Obika S, Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide,Bioorg Med Chem. 2023 Jan 15;78:117149. doi: 10.1016/j.bmc.2022.117149.
  45. Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
    Masui O, Corbel C, Nagao K, Endo TA, Kezuka F, Diabangouaya P, Nakayama M, Kumon M, Koseki Y, Obuse C, Koseki H, Heard E.Nat Cell Biol. 2023 Jan;25(1):134-144. doi: 10.1038/s41556-022-01047-y. Epub 2023 Jan 12.PMID: 366355054
  46. Sakurai Y, Yamaguchi T, Yoshida T, Horiba M, Inoue T, Obika S, Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2′-OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase, J Org Chem. 2023 Jan 6;88(1):154-162. doi: 10.1021/acs.joc.2c02038.
  47. Quantitative Microscopic Observation of Base-Ligand Interactions via Hydrogen Bonds by Single-Molecule Counting, Takashima, Y.; Komoto, Y.; Ohshiro, T. Nakatani, K.; Taniguchi, M. J. Am. Chem. Soc.2023, 145, 1310-1318. doi: 10.1021/jacs.2c11260.
  48. A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 31, Shibata, T.; Nakatani, K. Bioorg. Med. Chem. Lett. 2022, 79, 129082. doi: 10.1016/j.bmcl.2022.129082.
  49. Inhibitory Effects of Mismatch Binding Molecule on the Repair Reaction of Uracil-containing DNA, Ulhusna, A.; Murata, A.; Nakatani, K. Biochemistry 2022, 61, 2522-2530. doi: 10.1021/acs.biochem.2c00344.

2022

  1. Hamajima R, Tina L., Minami S, Nouda R, Jeffery A. N., Yamasaki M, Kobayashi N, Kanai Y, Kobayashi T. A reverse genetics system for human rotavirus G2P[4]. J Gen Virol. 2022 Dec;103(12):001816. doi: 10.1099/jgv.0.001816.
  2. RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
    Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A.Commun Biol. 2022 Dec 28;5(1):1420. doi: 10.1038/s42003-022-04369-7.PMID: 36577784 Free PMC article.
  3. Tumor cell plasticity in endometrioid carcinoma is regulated by neuronal membrane glycoprotein M6-b.
    Kusumoto S, Ikeda JI, Kurashige M, Maeno-Fujinami E, Tahara S, Matsui T, Nojima S, Okuzaki D, Morii E. Oncol Lett. 2022 Dec 14;25(2):45. doi: 10.3892/ol.2022.13631.
  4. Takegawa-Araki T, Yasukawa K, Iwazaki N, Maruyama H, Furukawa H, Sawamoto H, Obika S,Parallel synthesis of oligonucleotides containing N-acyl amino-LNA and their therapeutic effects as anti-microRNAs, Org Biomol Chem. 2022 Dec 7;20(47):9351-9361. doi: 10.1039/d2ob01809h.
  5. Osawa T, Ren Q, Obika S, Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3′-End, Molecules. 2022 Dec 3;27(23):8501. doi: 10.3390/molecules27238501.
  6. Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding, Takashima, Y.; Murata, A.; Iida, K.; Sugai, A.; Hagiwara, M. and Nakatani, K. ACS Chem. Biol. 2022, 17, 2817-2827.doi: 10.1021/acschembio.2c00452.
  7. Kato Y, Watanabe H. The mechanism for establishing the binary sex with environmental signals in the crustacean Daphnia magna. In: Tanaka, M., Tachibana, M. (eds) Spectrum of Sex. Springer, Singapore. 2022 Nov pp.203-219 doi: 10.1007/978-981-19-5359-0_12
  8. Yamaji R, Nakagawa O, Kishimoto Y, Fujii A, Matsumura T, Nakayama T, Kamada H, Osawa T, Yamaguchi T, Obika S, Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides,Bioorg Med Chem. 2022 Oct 15;72:116972. doi: 10.1016/j.bmc.2022.116972.
  9. Sugihara R, Kato Y, Mori T, Kawahara Y. Alignment of single-cell trajectory trees with CAPITAL. Nat Commun. 2022 Oct 14;13(1):5972. doi: 10.1038/s41467-022-33681-3.
  10. Tirta YK, Adachi S, Perez CAG, Adhitama N, Nong QD, Natsume T, Kato Y, Watanabe H. CELF1 represses Doublesex1 expression via its 5′ UTR in the crustacean Daphnia magna. PLoS One. 2022 Oct 14;17(10):e0275526. doi: 10.1371/journal.pone.0275526.
  11. Ogawa K, Yamada K, Etoh T, Kitagawa M, Shirasaka Y, Noguchi K, Kobayashi T, Nishizono A, Inomata M. Development of an Oncolytic Mammalian Orthoreovirus Expressing the Near-Infrared Fluorescent Protein iRFP720. Journal of Virological Methods, 2022, Oct;308:114574.doi: 10.1016/j.jviromet.2022.114574.
  12. Ngan T. K. P., Nishimura S, Shimizu-Onda Y, Quang D. T., Komine-Aizawa S , Pattara K., Okitsu S , Sato S, Kobayashi T, Niwat M., Hayakawa S, Ushijima H. Emerging norovirus GII.4 Sydney[P31] causing acute gastroenteritis outbreak in children in Japan, during COVID-19, 2021. J Infect Chemother, 2022 Sep;28(9):1347-1351. doi: 10.1016/j.jiac.2022.05.015.
  13. Nojima S, Ishida S, Terayama K, Matsumoto K, Matsui T, Tahara S, Ohshima K, Kiyokawa H, Kido K, Ukon K, Yoshida SY, Mitani TT, Doki Y, Mizushima T, Okuno Y, Susaki EA, Ueda HR, Morii E. A Novel Three-Dimensional Imaging System Based on Polysaccharide Staining for Accurate Histopathological Diagnosis of Inflammatory Bowel Diseases. Cell Mol Gastroenterol Hepatol. 2022;14(4):905-924. doi: 10.1016/j.jcmgh.2022.07.001.
  14. Yamada, T.; Furuita, K.; Sakurabayashi, S.; Nomura, M.; Kojima, C.; and Nakatani, K. NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA. Nucleic Acids Res. 2022 Sep 12:gkac740. doi: 10.1093/nar/gkac740.
  15. Yamazaki T, Yamamoto T, Hirose T. Micellization: A new principle in the formation of biomolecular condensates. Front Mol Biosci. 2022 Aug 29;9:974772. doi: 10.3389/fmolb.2022.974772.
  16. Yamamoto T, Yamazaki T, Hirose T. Triblock copolymer micelle model of spherical paraspeckles. Front Mol Biosci. 2022 Aug 22;9:925058. doi: 10.3389/fmolb.2022.925058.
  17. Matsushita M, Fujita K, Hatano K, Hayashi T, Kayama H, Motooka D, Hase H, Yamamoto A, Uemura T, Yamamichi G, Tomiyama E, Koh Y, Kato T, Kawashima A, Uemura M, Nojima S, Imamura R, Mubeen A, Netto GJ, Tsujikawa K, Nakamura S, Takeda K, Morii E, Nonomura N. High-fat diet promotes prostate cancer growth through histamine signaling. Int J Cancer. 2022 Aug 15;151(4):623-636. doi: 10.1002/ijc.34028.
  18. Onishi T, Takashima T, Kurashige M, Ohshima K, Morii E. Mutually exclusive expression of EZH2 and H3K27me3 in non-small cell lung carcinoma. Pathol Res Pract. 2022 Aug 12;238:154071. doi: 10.1016/j.prp.2022.154071.
  19. Nakatsubo D, Maeda Y, Hosokawa K, Kawada S, Okamoto M, Shimagami H, Tada T, Kiyokawa H, Sato K, Tahara S, Morii E, Narazaki M, Kumanogoh A, A case of relapsing polychondritis localized to the laryngeal cartilage in which FDG-PET/CT was helpful for diagnosis. Scand J Rheumatol 2022 Aug 10;1-3. doi: 10.1080/03009742.2022.2103937.
  20. Matsui T, Iwasa A, Mimura M, Taniguchi S, Sudo T, Uchida Y, Kikuta J, Morizono H, Horii R, Motoyama Y, Morii E, Ohno S, Kiyota Y, Ishii M. Label-free multiphoton excitation imaging as a promising diagnostic tool for breast cancer. Cancer Sci. 2022 Aug;113(8):2916-2925. doi: 10.1111/cas.15428.
  21. Ichihara S, Nagao K, Sakaguchi T, Obuse C, Sado T. SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice. Development. 2022 Aug 1; 149(15): dev200864. doi: 10.1242/dev.200864.
  22. Tsuchihashi K, Miyoshi N, Fujino S, Kitakaze M, Ohue M, Danno K, Nakamichi I, Ohshima K, Morii E, Uemura M, Doki Y, Eguchi H. Risk Factors for Predicting Lymph Node Metastasis in Submucosal Colorectal Cancer. J Anus Rectum Colon. 2022 Jul 28;6(3):181-189. doi: 10.23922/jarc.2022-002.
  23. Yoshida T, Morihiro K, Naito Y, Mikami A, Kasahara Y, Inoue T, Obika S. Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides. Nucleic Acids Res. 2022 Jul 22;50(13):7224-7234. doi: 10.1093/nar/gkac562.
  24. Yasumizu Y, Ohkura N, Murata H, Kinoshita M, Funaki S, Nojima S, Kido K, Kohara M, Motooka D, Okuzaki D, Suganami S, Takeuchi E, Nakamura Y, Takeshima Y, Arai M, Tada S, Okumura M, Morii E, Shintani Y, Sakaguchi S, Okuno T, Mochizuki H. Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma. Nat Commun. 2022 Jul 22;13(1):4230. doi: 10.1038/s41467-022-31951-8.
  25. Yamasaki T, Horie T, Koyama S, Nakao T, Baba O, Kimura M, Sowa N, Sakamoto K, Yamazaki K, Obika S, Kasahara Y, Kotera J, Oka K, Fujita R, Sasaki T, Takemiya A, Hasegawa K, Minatoya K, Kimura T, Ono K. Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways. Sci Rep. 2022 Jul 14;12(1):11984. doi: 10.1038/s41598-022-16017-5.
  26. Wu Y, Li P, Liu L, Goodwin AJ, Halushka PV, Hirose T, Nakagawa S, Zhou J, Liu M, Fan H. lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta. Mol Ther. 2022 Jul 6;30(7):2618-2632. doi: 10.1016/j.ymthe.2022.03.011.
  27. Fukada A, Takahashi T, Kurokawa Y, Asaoka T, Teranishi R, Saito T, Yamamoto K, Yamashita K, Tanaka K, Makino T, Nakajima K, Umeda D, Morii E, Hirota S, Eguchi H, Doki Y. Laparoscopic resection for recurrent gastrointestinal stromal tumors and paraganglioma in a patient with Carney-Stratakis syndrome: A case report. Asian J Endosc Surg. 2022 Jul 6. doi: 10.1111/ases.13104.
  28. Kubo A, Tanei T, R Pradipta A, Morimoto K, Fujii M, Sota Y, Miyake T, Kagara N, Shimoda M, Naoi Y, Motoyama Y, Morii E, Tanaka K, Shimazu K. Comparison of “click-to-sense” assay with frozen section analysis using simulated surgical margins in breast cancer patients. Eur J Surg Oncol. 2022 Jul;48(7):1520-1526. doi: 10.1016/j.ejso.2022.04.003.
  29. Samejima H, Ose N, Sakurai T, Nagata H, Morii E, Shintani Y. G-CSF-producing left lung squamous cell carcinoma positive for ROS1 rearrangements completely resected after neoadjuvant radiation chemotherapy: A case report. Respir Med Case Rep. 2022 Jun 27;38:101697. doi: 10.1016/j.rmcr.2022.101697.
  30. Yamada S, Kijima N, Kinoshita M, Shinzaki S, Sato K, Kido K, Hirayama R, Kagawa N, Takehara T, Morii E, Kishima H. Cerebellopontine angle metastasis of a neuroendocrine tumor mimicking vestibular schwannoma: A case report. Surg Neurol Int. 2022 Jun 23;13:264. doi: 10.25259/SNI_117_2022.
  31. Nakagawa S, Yamazaki T, Mannen T, Hirose T. ArcRNAs and the formation of nuclear bodies. Mamm Genome. 2022 Jun; 33(2):382-401. doi: 10.1007/s00335-021-09881-5.
  32. Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1. Nakamori M, Shimizu H, Ogawa K, Hasuike Y, Nakajima T, Sakurai H, Araki T, Okada Y, Kakita A, Mochizuki H. Brain Commun. 2022 Jun 10;4(3) : fcac154. doi: 10.1093/braincomms/fcac154.
  33. Umehara T, Arita H, Miya F, Achiha T, Shofuda T, Yoshioka E, Kanematsu D, Nakagawa T, Kinoshita M, Kagawa N, Fujimoto Y, Hashimoto N, Kiyokawa H, Morii E, Tsunoda T, Kanemura Y, Kishima H. Revisiting the definition of glioma recurrence based on a phylogenetic investigation of primary and re-emerging tumor samples: a case report. Brain Tumor Pathol. 2022 Jun 6. doi: 10.1007/s10014-022-00438-1.
  34. Nouda R, Kawagishi T, Kanai Y, Shimojima M, Saijo M, Matsuura Y, Kobayashi T. The nonstructural p17 protein of a fusogenic bat-borne reovirus regulates viral replication in virus species- and host-specific manners. PLOS Pathogens. 2022 Jun 2;18(6):e1010553. doi: 10.1371/journal.ppat.1010553.
  35. Sasaki T, Hirakawa Y, Yamairi F, Kurita T, Murahashi K, Nishimura H, Iwazaki N, Yasuhara H, Tateoka T, Ohta T, Obika S, Kotera J. Altered Biodistribution and Hepatic Safety Profile of a Gapmer Antisense Oligonucleotide Bearing Guanidine-Bridged Nucleic Acids. Nucleic Acid Ther. 2022 Jun;32(3):177-184. doi: 10.1089/nat.2021.0034.
  36. Kiyokawa H, Abe M, Matsui T, Kurashige M, Ohshima K, Tahara S, Nojima S, Ogino T, Sekido Y, Mizushima T, Morii E. Deep Learning Analysis of Histologic Images from Intestinal Specimen Reveals Adipocyte Shrinkage and Mast Cell Infiltration to Predict Postoperative Crohn Disease. Am J Pathol. 2022 Jun;192(6):904-916. doi: 10.1016/j.ajpath.2022.03.006.
  37. Omuro S, Yamaguchi T, Kawase T, Terasaki M, Hirose K, Obika S. Physicochemical property evaluation of modified oligonucleotides by traveling-wave ion mobility mass spectrometry. Rapid Commun Mass Spectrom. 2022 May30;36(10):e9279. doi: 10.1002/rcm.9279.
  38. Sano E, Suzuki T, Hashimoto R, Itoh Y, Sakamoto A, Sakai Y, Saito A, Okuzaki D, Motooka D, Muramoto Y, Noda T, Takasaki T, Sakuragi J, Minami S, Kobayashi T, Yamamoto T, Matsumura Y, Nagao M, Okamoto T, Takayama K. Cell response analysis in SARS-CoV-2 infected bronchial organoids. Commun Biol. 2022 May 30;5(1):516. doi: 10.1038/s42003-022-03499-2.
  39. Hussain F, Rahman FI, Saha P, Mikami A, Osawa T, Obika S, Rahman SMA. Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials. Molecules. 2022 May 29;27(11):3499. doi: 10.3390/molecules27113499.
  40. Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit. Hsu H T, Murata A, Dohno C, Nakatani K, Chang K. Nucleic Acids Res. 2022, May 20;50(9) 5369-5383. doi:org/10.1093/nar/gkac257.
  41. Murai H, Kodama T, Maesaka K, Tange S, Motooka D, Suzuki Y, Shigematsu Y, Inamura K, Mise Y, Saiura A, Ono Y, Takahashi Y, Kawasaki Y, Iino S, Kobayashi S, Idogawa M, Tokino T, Hashidate-Yoshida T, Shindou H, Miyazaki M, Imai Y, Tanaka S, Mita E, Ohkawa K, Hikita H, Sakamori R, Tatsumi T, Eguchi H, Morii E, Takehara T. Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma. Hepatology. 2022 May 14. doi: 10.1002/hep.32573.
  42. Kita R, Osawa T, Obika S. Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis. RSC Chem Biol. 2022 Apr 19;3(6):728-738. doi: 10.1039/d1cb00240f.
  43. Kato Y, Watanabe H. Regulation of Doublesex1 Expression for Environmental Sex Determination in the Cladoceran Crustacean Daphnia. Front Cell Dev Biol. 2022 Apr 13; 10:881255. doi: 10.3389/fcell.2022.881255.
  44. Beck G, Shigenobu K, Ukon K, Yamashita R, Yonenobu Y, Morii E, Hasegawa M, Ikeda M, Murayama S, Mochizuki H. An autopsy case of Alzheimer’s disease with amygdala-predominant Lewy pathology presenting with frontotemporal dementia-like psychiatric symptoms. Neuropathology. 2022 Apr;42(2):147-154. doi: 10.1111/neup.12786.
  45. Tung P., Hatazawa R, Komoto S, Nishimura S, Pattara K., Ngan T. K. P., Okitsu S, Kobayashi T , Niwat M., Hayakawa S, Ushijima H. Whole genome sequence of an uncommon G9P[4] species A rotavirus containing DS-1-like (genotype 2) genes in Japan. Archives of Virology, 167(7): 1603-1606, 2022.DOI: 10.1007/soo705-022-05462-2
  46. Tung P., Kobayashi M, Nagasawa , Hatazawa R, Ngan T. K. P., Miyashita H, Komoto S, Tajima T, Baba T, Okitsu S, Pattara K., Niwat M., Kimura H, Kobayashi T, Hayakawa S, Ushijima H. Whole genome sequencing and evolutionary analysis of G8P [8] rotaviruses emerging in Japan. Virus disease, 33(2):215-218,2022. DOI: 10.1007/S1333-022-00765-z